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Tag Archive for: Cannabinoids

CBD Oils

How CBD Helps In Relieving Pain- 3 Things You Should Know!

January 27, 2021/0 Comments/in Blog/by John Ryan

People from different parts of the world are cultivating cannabis for thousands of years for recreational, medicinal, and even spiritual purposes. Then came the last few decades, when its cultivation and consumption were restricted in many developed countries, the USA being one of them. However, with time, studies from different parts of the world came forward, proving this herb’s medicinal potentials. CBD oil for pain relief has become something many are benefiting from. As a result, many countries have started lifting the ban on cannabis consumption as well as cultivation.

Cannabis Plant

In December 2020, the US house of representatives issued a landmark bill decriminalizing cannabis. This brought good news for the people who want to explore the therapeutic effects of CBD. Cannabidiol oil is an oil derived from the extracts of cannabis Sativa. As the research on CBD oil for pain relief acquired momentum, researchers and people have started claiming its effectiveness against many illnesses including pain and inflammation.

The studies started confirming the therapeutic benefits of cannabidiol oil. As a result, products like CBD full spectrum for pain, capsules, topical solutions, and similar products started filling consumers’ shopping carts. CBD can provide relief from many modern-day problems like depression and anxiety; however, this article concentrates on the effect of CBD on pain and three important things you know before using it.

CBD does not produce a high

CBD is a compound that comes from the cannabis family, which is famously known to induce euphoric effects. Tetrahydrocannabinol, a chemical present in the cannabis plant, is responsible for such psychoactive effects. CBD does not contain THC. Therefore, it does not induce any kind of ‘high’ after its consumption.

CBD oil for Pain Relief from chronic pain

Several disorders like arthritis, sclerosis, immunological disorders, etc., cause pain due to malfunctioning of respective systems of the body. Many people use CBD to manage this pain. Now, experts believe that CBD oil for pain relief happens by interacting with the body’s endocannabinoid system.

Endocannabinoid System: ECS is involved in maintaining various bodily functions like immune responses, sleep, and pain perception. The following three components collectively make the ECS:

  1. Cannabinoid Receptors named as CB1 and CB2

CB1: Found in the central nervous system, i.e., nerves attached to the spinal cord and the brain. They are responsible for our perception of pain.

CB2: Found on the nerves of the peripheral nervous system and immune cells.

  1. Cannabinoids produced by the body: Endocannabinoids

  2. Enzymes regulating the consumption of cannabinoids

CBD displays a wide range of effects on both the nervous systems and the immune system. CBD interacts with CB1 or CB2 receptors to bring out pain-relieving actions.

Mechanisms behind pain-relieving actions of CBD

CBD Oil Full Spectrum

CBD oil for pain relief resulting from various disorders like arthritis, multiple sclerosis, neuropathic pain, and chronic pain. From its effects on cannabinoid receptors to reducing inflammation, several mechanisms are proposed to explain how CBD provides relief from pain. For many years, researchers believed that cannabinoids reduce pain by activating CB1 and CB2 receptors of ECS. Along with the receptors ECS, CBD also interacts with serotonin receptors, decreasing the pain’s intensity.

Furthermore, experts state that CBD increases the levels of anandamide in the body. Anandamide is a biologically active compound that regulates pain by reducing its perception. CBD also lowers inflammation, which eventually benefits people suffering from pain caused by immune disorders.

Choosing the CBD Oil For Pain Relief

CBD oil for pain relief

CBD is available in different forms like capsules, gummies for oral consumption, and crèmes and tinctures for topical application. The action of CBD oil for pain relief on the body depends on its route of administration. Therefore, knowing the difference between oral and topical CBD is essential to make the decision.

Topical CBD

Topical benefits of CBD is available in the forms of tincture, creams, and balms. When you apply them around the pain area, your skin absorbs it, and CBD starts interacting with cannabinoid receptors. Topicals start showing their effects in a short time, and that is why many people chose them.

Oral CBD

Tablets, capsules, oil, and gummies of CBD fall under this category. There are two types of consuming oral CBD:

  • Ingestion, where you can directly take the liquid, tablet, or gummy – In this type, the best CBD oil for pain management takes time to show its effect as the molecules pass through the digestive system.

  • Sublingual consumption, where you place the drops of CBD oil under the tongue – The blood vessels below your tongue rapidly absorb the oil, which enters the bloodstream and rapidly travels to the receptors of ECS.

You must be thinking about which one of the above is the best method, but the answer to this question lies in your needs. Topical CBD oil for pain relief works great when you want targeted action, like muscle or joint pain. On the other hand, if you are dealing with a bigger problem than that, you can think of using oral CBD for pain relief. The oral forms cast long-lasting effects, which is why they are used for pain caused by inflammation.

Final Thoughts

Cannabidiol Tincture

From daily activities to our outlook towards life, pain can negatively affect various parts of our lives. Nobody wants to live in pain, but some chronic illnesses make it difficult to get through the day. Traditional medications to treat the pain, however many work on the symptom, not on the cause. On the other hand, CBD full spectrum and CBD Isolate with it’s medicinal potential comes forward as a promising solution due to their direct effects on various pain receptors.

MARIJUANA LEAF

Differences Between CBD And CBDA

January 15, 2020/0 Comments/in Blog/by John Ryan

The main differences between CBD and CBDA from a health perspective…

Health Benefits of Cannabis

The world of cannabis is immense. As scientists began to explore the plant in detail due to its health benefits, they began to understand this miraculous cannabis world.

Within the simple plant lies hundreds of chemicals that work the magic in our body to cure a large spectrum of diseases, both physical and mental.

When we breakdown the components of cannabis, we end up with about 113 cannabinoids and a range of terpenes. Among the cannabinoid THC, CBD, and CBN has been of primary interest to the scientist community.

Cannabis leaf

Cannabinoids come in various forms. The cannabinoid oils and pastes have an impact on the body because of the interaction with the endocannabinoid system.

To understand how these different cannabinoids can influence our health, we need to start from its interaction with our body. We will discuss two cannabinoids in detail – CBD and CBDa.

What are CBD and CBDa?

Among the various cannabinoids of cannabis are CBD and CBDa. CBD is a short form for cannabidiol, and it takes the credit for the various medicinal values one can derive from the cannabis plant.

CBD oils and other products are available on the market for treating ailments such as chronic pain, epileptic seizures. The compound does not have psychoactive effects on the body like THC. Cannabidiol acid (CBDa), on the other hand, converts to CBD when heated.

The decarboxylation process, such as during smoking or vaping, helps convert this acid into cannabidiol, which has various health benefits. CBDa is the form available in the raw plant, and it is the acid precursor of CBD.

The beginning compound of both these cannabinoids is CBDa. CBDa is the natural form in which the cannabinoids are present in the cannabis plant.

In the presence of a CBDa synthase, it converts into CBDa, which further converts into CBD during decarboxylation. Both these compounds share common properties and health effects as they are derivatives.

Research shows that CBD and CBDa have anti-inflammatory properties and anti-proliferative properties and many more health benefits to count.

CBDA and CBD

Benefits of CBD vs CBDA

The common ancestor to the two compounds means that the interaction of them with our endocannabinoid system is the same. The only difference is their target receptors.

While CBD is known to interact with adenosine, vanilloid, and serotonin receptors, CBDa mostly works in blocking COX-1 and COX2 receptors to reduce inflammation.

CBD also inhibits CPR55 receptors that help improve cancer-fighting properties, balancing blood pressure and bone density. The best strains of marijuana will give you a chance to experience both these cannabidiols.

CBD is among the first few cannabinoids to have progressed rapidly in the medical community. Currently, FDA approved medication known as Epidiolex is available for the treatment of epileptic seizures, which contains CBD. It stands as solid proof for CBD`s effective anti-seizure properties.

CBD has antipsychotic properties, which makes it the right match to pair with THC dominant compounds to reduce the effects. It is among the greatest advantages of full-spectrum CBD oils, where the cannabinoids complement and compensate for disadvantages, if any, and give the best possible health benefits.

CBD has been proven extremely effective for treating mental ailments such as depression, anxiety, PTSD, OCD, and panic disorders. CBD has also proven to be useful for treating conditions related to involuntary muscle spasms such as Parkinson’s disease, Cerebral Palsy, Multiple sclerosis.

What is CBDA?

A large body of research about the usefulness of CBDa, its efficiency for post-chemotherapy treatment is a fascinating area to explore.

While currently, cannabis-based recovery during this stage is under trails, studies indicate that CBDa could have a particularly influential role in coping with side effects of chemotherapy.

There is evidence to show that CBDa can help reduce nausea, vomiting, tumor proliferation, anxiety, as well as inflammation. CBDa could be the road to a healthy recovery for cancer patients after the therapy. CBDa has proven to be useful for antitumor activities, especially in the case of breast cancer patients.

A study from 2012 held in Hokuriku University backs up this claim by showing that CBDa helps inhibit breast cancer cell migration.

The various ways to consume CBD and CBDa

The type of consumption determines bioavailability or delivery such as THC delivery using smoking, vaping. The various forms of CBD products known to us are oils, vaping juices, tinctures, creams, lotions, capsules that are available on the market today.

CBD infused juices, and other such edibles are also available. In terms of CBDa, the options are quite limited. The reason is that CBDa is present only when the plant extracts are in its raw form, or it gets converted to CBD.

Hence CBDa ingestible such as through fruit juices, salad dressing, drops, syrups, capsules are mostly available.

Which one to prefer?

CBD has been the center of medical research for almost a decade now. Hence the level of research climbing up to clinical trials is higher in this case.

Whereas CBDa is still a new compound of interest in this sector. Thus most of the available work is still restricted to the preclinical stage of animal trials.

Some claim that CBD is a superior compound to CBDa as it offers more medicinal benefits comparatively. But unless the level of research matches, there isn’t a right or wrong side in this debate.

CBDA tincture

In terms of consumption, the fact that patients would prefer an alternative form of medications to smoke or consumables suggests that CBDa could have a broad scope for medicinal use.

CBDa is a rather pure form of the cannabidiol which eliminates problems of smoke, toxic residue and delivers the best possible health benefits.

But studies indicate that CBD is absorbed faster into the system as compared to CBDa. Hence scientists are looking for combining the two compounds or preparing medications to ensure you derive the best value from both.

Together they create miracles

While we wish to understand the difference between the cannabinoids genuinely, it is essential to know that the beauty of cannabis lies in giving a united front of cannabinoids for health benefits.

Today, scientists understand the reason why full-spectrum oils are more potent than isolated varieties. The complementary properties of the cannabinoids help elevate the best in each of them and suppress the negatives.

It makes cannabis as a whole an incredible compound to enjoy various health benefits. A full cannabinoid and terpene profile could be the right choice for seeking relief from various physical and mental ailments.

cannabinoid

Cannabinoid Research That Time Forgot

August 20, 2019/0 Comments/in Blog/by John Ryan

Timemagazine made a flawed, sensationalistic attempt at covering cannabinoid research in an article. The piece details the effects of a synthetic cannabinoid (called JWH-133) and its ability to deter cocaine addiction in an animal model by activating the CB2 receptor in the brain. The implications of this study imply that cannabinoids could be potentially used as an “exit” drug for cocaine users. ButTimeconfused the synthetic drug used in the study with a natural substance called cannabidiol or CBD.

CBD and Cocaine

Cannabinoid Receptors And Cocaine Addiction

Unfortunately, the seemingly good news about CB2 receptors and the treatment of cocaine addiction was overshadowed by a plethora of inaccurate scientific information.

Here are the three main points thatTimeforgot:

  • CBD does not activate CB2 receptors at a reasonable concentration.This crucial information was published in 1996. In test-tube experiments, CBD can only activate the CB2 receptor at a concentration unachievable through any known or conventional route of administration. If, for instance, a patient had an IV hooked up to a vat of nearly pure CBD, then theremightbe enough CBD to affect receptor dynamics and thus lead to the activation of CB2 receptors. In short, CBD may be able to treat cocaine addiction, but not by acting through cannabinoid receptors.
  • Dr. Gardner and his team (referred to in theTimearticle) looked at the effects of a synthetic cannabinoid, not actual CBD, in relation to cocaine addiction.To be clear: JWH-133 activates CB2 receptors while CBD does not. (It’s essential to note that more JWH compounds are becoming illegal each day. In the last few months, several JWH compounds have been listed as either Schedule 1 of the federalControlled Substances Act,placed on the DEA watch list or banned by new state laws.)
  • Timemagazine glaringly overlooked the most relevant research done on the effects ofactual CBD (not a synthetic cannabinoid like JWH-133) and cocaine addictionby Raphael Mechoulam, one of the most noted Cannabis researchers in history. Dr. Mechoulam is credited as the first scientist to isolate THC as the primary ingredient inCannabisback in 1964 and he continues to produce groundbreaking cannabis research. His important 2004 study looked at CBD and cocaine addiction but the research cited byTimenever even mentions CBD.

The Need For More Cannabinoid Research

One of the most basic concepts in cannabinoid science is that THC activates CB1 and CB2 receptors, but CBDdoes notactivate CB1 and CB2 receptors. To refute this fundamental understanding of cannabinoid receptors is an insult to the scientific community and ultimately does more harm than good. As a scientist, this type of research is extremely complex andallnews organizations will need to do a better job when conveying information to the public.

Understanding CB1 and CB2

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